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Associate Scientist, Prod Dev - Early Stg

Job Description

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

Collaborate with research and preclinical to ensure phase-appropriate and species-specific formulations are developed and compounded in support of preclinical studies. Assist in characterizing the developability of new therapeutic modalities (small molecules and biologics). Execute various studies to support product advancement from early discovery through clinical phase. Maintain laboratory equipment and perform calibrations/verifications as needed.

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Your Contributions (include, but are not limited to):
  • Evaluate physiochemical properties of new development compounds (across small molecule and biologic modalities) to identify developable candidates

  • Develop and characterize formulations for use in non-clinical studies

  • Measure biopharmaceutical properties, pkA and logP, of materials via UV/Metric and pH/Metric titration techniques

  • Execute thermodynamic and kinetic solubility studies to aid in method development processes

  • Operate and maintain laboratory instrumentation and equipment, and facilitate service with

    technicians as needed

  • Collaborate and communicate with other groups in-house to ensure conclusions from data

    generated are applied correctly and used widely and effectively

  • Assemble and maintain documentation of data to allow efficient retrieval of results

  • Performs other duties as assigned

Requirements:
  • BS/BA degree in Chemistry, Chemical Engineering, Materials Science, or related field and some experience in a chemistry, analytical, or characterization laboratory setting required; Experience with characterization equipment such as PXRD, DSC, TGA, and SEM a plus OR

  • MS/MA degree in Chemistry, Chemical Engineering, Materials Science, or related field preferred and some lab or industry experience preferred

  • Some knowledge of a cGMP-regulated environment, including familiarity of relevant US/EU regulatory and quality requirements, standards, and practices

  • Familiarity with biotech/pharma manufacturing operations, product and process development, finance, and supply chain operations

  • Possess familiarity of physical & analytical techniques as they pertain to biopharmaceutical properties

  • Ability to learn quickly and think independently

  • Familiarity with the development and execution of chemical and instrumental methods (e.g. HPLC, solubility analysis, DLS, viscometer, osmometer, DSC, TGA, PXRD, particle-size analysis, GVS, PLM, T3, and SEM) of analyses for development compounds, raw materials, intermediates, drug products, and packaging materials

  • Able to execute experiments efficiently and suggest small process improvements

  • Able to recognize patterns or inconsistencies in data results

  • Able to deduce meaningful results while conducting routine analyses or troubleshoot minor issues. Good knowledge of one scientific discipline

  • Developing knowledge of scientific principles, methods and techniques

  • Good knowledge and some experience working with discipline specific laboratory equipment/tools

  • Ability to work as part of a team

  • Good computer skills

  • Developing communications, problem-solving, analytical thinking, planning and organization skills

  • Detail oriented

  • Understands importance of meeting deadlines

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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The hourly rate we reasonably expect to pay is $33.98-$48.01. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 15% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

 

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