The Dana-Farber Cancer Institute seeks a scientist with experience in molecular biology, biochemistry, biophysics and preclinical characterization of small molecules at the newly established Center for Therapeutic Discovery (CTD). This is a unique opportunity for a PhD-level biologist to be involved in high-impact drug discovery projects in the newly developed center at Dana-Farber Cancer Institute.

The scientist will play an important role defining and establishing the biochemical and biophysical assays used to screen and optimize novel small molecule therapeutics. You will work closely with the chemistry and pharmacology groups to best support the development of novel therapeutics. The candidate will provide insights that impact the direction of our research, while also driving lab-based innovations. The individual will regularly present progress to the rest of the group and key stakeholders. You will interface with the Center leadership and with faculty and staff at the Dana-Farber Cancer Institute. To be successful, we expect you to have strong technical, communication, and organizational skills.

We offer competitive compensation at the level of Research Scientist Track at the Dana-Farber, commensurate with experience, and opportunities for career advancement and growth, and be a member of a vibrant and inclusive research community.

• Independently plan, manage, and perform biochemical experiments. Develop project proposals, timelines and resource needs, working closely with the Portfolio Manager and leadership.  Monitor milestones and ensure deliverables are completed on time.
• Collect and analyze experimental data and identify next steps based on outcomes.
• Train research technicians and other scientific staff in methods/techniques.

• Develop, perform, and analyze screening assays to evaluate the activity of small molecules.

• Develop, implement, and deliver mechanistic insights into the mechanism of action.
• Work closely with chemistry and biology teams to guide compound optimization and project progression.
• Prepare presentations and present project status and outcomes at internal and external meetings.
• Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects.
• Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings).

• Ph.D. in Biochemistry, Biophysics, Protein sciences or related fields (2+ years of relevant postdoc or industry experience preferred).

• Expert in biochemical and biophysical characterization of small molecules and establishment of screening cascades to identify structure activity relationships.

• Skilled in design and establishment of biochemical assays including enzymatic, HTRF, and AlphaScreen.

• Experience with biophysical binding assays including SPR, DSF, ITC.
• Experience in protein production and x-ray crystallography a plus.
• Demonstrated leadership in research projects related to drug development or translational applications.
• Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals.
• Excellent communication and presentation skills.
• Demonstrated ability to work in a fast-paced and dynamic environment.
• Ability to work independently as well as in a collaborative and team environment.
• Proficiency in all common Microsoft Office and GraphPad Prism software.
• Excellent organizational and prioritization skills. Strong attention to detail.

Located in Boston and the surrounding communities, the Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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